Abandoned Clinical Trials: Lives at Risk After U.S.A.I.D. Cuts

Thu Mar 13 2025 08:15:58 GMT+0200 (Eastern European Standard Time)
Abandoned Clinical Trials: Lives at Risk After U.S.A.I.D. Cuts

The decision by the Trump administration to halt U.S.A.I.D. funding has led to dangerous situations for thousands involved in clinical trials worldwide.


Research participant Asanda Zondi faced an alarming situation when a trial she was part of was halted abruptly due to a government order, leaving her with an unmonitored medical device.

Asanda Zondi, a 22-year-old participant in a groundbreaking clinical trial in Vulindlela, South Africa, received a shocking phone call last Thursday instructing her to visit a local health clinic. The nurse informed her that the trial testing a silicone device aimed at preventing both pregnancy and HIV infection was terminating. She was urgently required for a medical procedure to remove the device, which had been left inside her as a result of the sudden shutdown.

This drastic measure came after the U.S. Agency for International Development (U.S.A.I.D.) withdrew its financial support from the study, complying with President Trump's recent executive order that halted all foreign aid for a minimum of 90 days. The abrupt cessation of funds has left numerous ongoing trials frozen, forcing researchers to abandon participants and cutoff vital monitoring and care.

This situation has provoked significant distress among trial participants, many of whom are unknowingly left with experimental drugs and devices in their bodies. As scientists face an ethical dilemma under strict stop-work orders — either to disobey the directive in order to care for their patients or remain compliant and risk potential harm — the global implications of this decision are profound.

The U.S. State Department, which now oversees U.S.A.I.D., has responded to inquiries regarding this matter by redirecting journalists to U.S.A.I.D.'s website, which is now largely devoid of operational information, listing only administrative leave notices for permanent employees. Secretary of State Marco Rubio has openly criticized U.S.A.I.D., labeling it as wasteful and aligned with a progressive agenda that contrasts sharply with Trump's foreign policy.

With sentiment in the scientific community growing increasingly urgent, many researchers express concern over the fate of participants caught in a political crossfire — raising ethical questions amidst a rapidly evolving international health crisis.

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