Dequenne's impact on the film industry was profound, with her career beginning in "Rosetta," a film that brought both a Palme d'or win and critical recognition at the Cannes Film Festival. Her powerful portrayal of a teenager facing dire circumstances captivated audiences and industry professionals alike. Luc Dardenne, the film's director, expressed his admiration, highlighting her ability to unify the film crew and enhance the project.

Throughout her career, Dequenne participated in various prominent films, including "La fille du RER" and "Pas Son Genre," and continued to shine until her last memory on the Cannes red carpet just a year ago. The francophone cinema community has expressed a collective loss with tributes flooding in, including a heartfelt message from French Minister of Culture Rachida Dati, recalling the actress as a significant talent taken too soon.

In October 2023, Dequenne revealed her diagnosis of adrenocortical carcinoma, and her struggles were poignantly shared with fans on social media. In a reflective post for World Cancer Day, she noted the difficult journey she faced, reminding us of the unpredictability of life and the tenacity required to fight such battles. Her legacy will continue to inspire future generations of filmmakers and audiences alike.