US news anchor Savannah Guthrie has posted a video message tearfully pleading for the return of her abducted mother and seeking proof from her captors that the 84-year-old is still alive.

We want to hear from you and we are ready to listen, the NBC host says, flanked by her siblings in the clip posted to Instagram. Please reach out to us.

Nancy Guthrie went missing in the middle of the night from her home in the US state of Arizona over the weekend. Authorities in Arizona said they suspect she was kidnapped and they are working with the FBI to authenticate a possible ransom note.

We are ready to talk, said the NBC host. However, we live in a world where voices and images are easily manipulated. We need to know without a doubt that she is alive and that you have her.

Pima County Sheriff's Office said they were still speaking with anyone who had contact with Nancy Guthrie last weekend, and that no suspect or person of interest had so far been identified.

Savannah Guthrie, joined by her sister Annie and brother Cameron, stated that they were aware of an alleged ransom note, which was sent to at least one media outlet. Mommy, if you are hearing this, you are a strong woman, Savannah said, her voice breaking, emphasizing that they would not rest until they were together again. Officials have warned Nancy Guthrie could be in dire health without her medication, as Savannah highlighted her mother's fragile condition.

U.S. President Donald Trump has commented on the case, directing federal law enforcement to assist in the matter, expressing the nation's prayers for the family. Pima County authorities continue to investigate, employing resources like dogs, drones, helicopters, and federal agents in the search for Nancy, who was last seen on Saturday evening.

The situation remains critical as families and officials seek answers amid growing concerns for Nancy's well-being.